Florfenicol Sodium Succinate

Tlhaloso e Khutšoanyane:


Tlhahisoleseling

Florfenicol Sodium Succinate
Lebitso la sehlahisoa: Florfenicol sodium succinate

Khemik'hale ea thepa:
Phofo e tšoeu kapa e tšoeu e bosoeu ba kristale ha e na monko ebile ha e senyehe, ha moea o le mongobo o phahameng. Sehlahisoa sena se qhibiliha hanyane ka har'a acetone, ethanol, se qhibilihang habonolo ka metsing, se nang le "florfenicol sodium".

Tšobotsi:
1. Florfenicol sodium e ntso e etsa hore Floridafenicol solubility ho 300mg / ml mme e eketsoe makhetlo a 400.
2. Florefenicol sodium e nkoang e etsa hore Florfenicol e be sekhahla sa phetho ka makhetlo a 200 ka potlako, ntle le ho qhibiliha ha bonolo, hang-hang ka metsing.
3. Florfenicol sodium e hlahisoang ke li-derivatives tsa Florfenicol, tse kenang 'meleng ka enzyme e kentsoeng ka mokhoa o hlakileng ho florfenicol le ts'ebetso e ntle ea mali ea nako e telele.
4. Ha e hloke ho nka karolo ha motsoako o ka sebelisoa ho tsamaiso ea bongaka, ho qoba litlamorao tsa ho sebelisa solvent ea motsoako (ho ntlafatsa ts'ireletso ea sethethefatsi, fokotsa masala).

Roko
Sehlahisoa sena ke tse tlisoang ke Florfenicol, ho latela molaoana oa sebopeho sa Prodrug e entse hore e be libaktheria tse fapaneng tsa gram tse ntle le gram mme e na le karolo ho mycoplasma.
Mochine oa antibacterial o na le subsit ea 50S ribosomal subunit, mme e thibela enzyme ea bohlokoa e hlokahalang bakeng sa synthesis ea protheine - peptidyl transase, e ka thibelang ka kotloloho mokokotlo oa aminoacyl-tRNA o kenyang li-receptors mokokotlong oa ribosome inhibitory peptide o atolositsoeng o sieang protheine ea baktheria e ke ke ea etsoa. . Sehlahisoa sena se ke ke sa eketsa feela ts'ebetso ea metsi a qhibilihang, le ts'ebetso ea molomo le ea ente ka tahlehelo ea vivo, kamora hore metabolism ea enzyme 'meleng e senyehe ka har'a li-esters le estor flenfenicol ester e hlotse ho hanyetsa baktheria. Ho tsepamisa maikutlo ho Florfenicol, ho bapala lithethefatsi tse sebetsang hantle haholo tse sebetsang ho setho sa 'mele, palo e nyane, e potlakile, nako e telele ea bophelo, khatello e phahameng ea plasma, nako e telele ho boloka mahloriso a plasma. Haholo-holo ke liphio excretion.
 
Matšoao
E sebelisoa ho lefu la likhoho E. coli le Serositis le tlhapi e bolaea litlhapi tsa salmon Aeromonas, Vibrio straillarum bakeng sa libaktheria tse hlokahallang likhomo, likolobe, ts'oaetso ea mala le likhohola tsa mycoplasma tse bakoang ke ho phefumoloha ho sa feleng.
 
Tekanyetso
Likhoho: seno se kopaneng sa metsi a 100L a 3.5-4g, mehlape, ka kilogram ea boima ba 'mele 20-25mg, hang ka letsatsi' me u sebelise matsatsi a mararo. IM: likhoho, likolobe, likhomo le nako ea kilogerama ea boima ba 'mele e le 15-20mg, e' ngoe le e 'ngoe ka 48h ka nako e le ngoe. sebelisa makhetlo a mabeli.

 


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